Products for Research Use Only
RegisterLogin

Orexin receptor modulator-1

CAT: 0804-HY-153458Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-153458Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Orexin receptor modulator-1 is an orexin receptor modulator. Orexin receptor modulator-1 can be used for the research of substance addiction, panic disorder, anxiety, post-traumatic stress disorder, pain, depression, seasonal affective disorder, an eating disorder, or hypertension[1].
CAS Number
2125735-57-9
UNSPSC
12352005
Target
Orexin Receptor (OX Receptor)
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/orexin-receptor-modulator-1.html
Solubility
10 mM in DMSO
Smiles
O=C(N1[C@@H]([C@@H](CC(F)(C1)F)C)CNC2=NC=C(C(F)(F)F)N=C2)C3=NN(C)C=C3C4=CC=C(C=C4)Cl
Molecular Formula
C23H22ClF5N6O
Molecular Weight
528.91
References & Citations
[1]Theodore M, et al. Halo-substituted piperidines as orexin receptor modulators. Patent. WO2017139603A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Orexin receptor modulator-1
CAS Number2125735-57-9
PubChem CID130298617
IUPAC Name[4-(4-chlorophenyl)-1-methylpyrazol-3-yl]-[(2S,3R)-5,5-difluoro-3-methyl-2-[[[5-(trifluoromethyl)pyrazin-2-yl]amino]methyl]piperidin-1-yl]methanone
Molecular FormulaC23H22ClF5N6O
Molecular Weight528.9
XLogP4.7
Topological Polar Surface Area75.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count5
Heavy Atom Count36
Formal Charge0
Complexity768
SMILES
C[C@@H]1CC(CN([C@@H]1CNC2=NC=C(N=C2)C(F)(F)F)C(=O)C3=NN(C=C3C4=CC=C(C=C4)Cl)C)(F)F
InChI
InChI=1S/C23H22ClF5N6O/c1-13-7-22(25,26)12-35(17(13)8-31-19-10-30-18(9-32-19)23(27,28)29)21(36)20-16(11-34(2)33-20)14-3-5-15(24)6-4-14/h3-6,9-11,13,17H,7-8,12H2,1-2H3,(H,31,32)/t13-,17-/m1/s1
InChIKey
MHAXBTDNJWJMQB-CXAGYDPISA-N
Chemical Structure
2D Structure
2D structure of Orexin receptor modulator-1
CAS: 2125735-57-9
CID: 130298617
Formula: C23H22ClF5N6O
MW: 528.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight528.9
XLogP34.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count5
Exact Mass528.1463779
Monoisotopic Mass528.1463779
Topological Polar Surface Area75.9 Ų
Heavy Atom Count36
Formal Charge0
Complexity768
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-U00429-01NOT Receptor Modulator 1
HY-162977Orexin receptor activator-1
HY-151876-01Glucocorticoid receptor modulator 1
HY-147560σ1 Receptor/μ Opioid receptor modulator 1
HY-U00420Opioid receptor modulator 1
HY-112699AMPA receptor modulator-1
HY-145370GluN2B receptor modulator-1
HY-109572GABAA receptor modulator-1
HY-110201-01Estrogen receptor modulator 1
HY-163065σ1 Receptor/μ Opioid receptor modulator 2

Alternative Products

CatalogName
GTR19230721-01Orexin receptor modulator-1
O7503-20Orexin 1 Receptor
319831Orexin Receptor 1
482579HCRTR1 (Orexin Receptor Type 1, Hypocretin (Orexin) Receptor 1)
208329Orexin 1 Receptor (Orexin receptor 1, HCRTR1, Orexin Receptor-1, Orexin Receptor Type 1, OX1R, Hypocretin 1 Receptor, Hypocretin Receptor 1, Hypocretin Receptor-1, Hypocretin Receptor Type 1)
O7503-20EOrexin 1 Receptor discontinued
AP86672Orexin receptor type 1
E51A09432Orexin Receptor 1 Antibody
T200707-01Orexin receptor activator-1
512357Orexin Receptor 1 discontinued

Popular Products