σ1 Receptor/μ Opioid receptor modulator 2

• UNSPSC Description:

  σ1 Receptor/μ Opioid receptor modulator 2 (compound 4x) is a dual μOR agonist/σ1R antagonist, and displays picomolar μOR agonism activity (EC50: 0.6 ± 0.2 nM) and good σ1R inhibitory activity (Ki: 363.7 ± 5.6 nM). σ1 Receptor/μ Opioid receptor modulator 2 exhibits robust analgesic effects in various pain models[1].

• Target Antigen:

  Opioid Receptor; Sigma Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/σ1-receptor-μ-opioid-receptor-modulator-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N(C1=CC=CC=N1)CC(N2CCC(CC2)C3=CC=CC=C3)CC)CC

• Molecular Weight:

  365.51

• References & Citations:

  [1]Miao Z, et al. A Novel Bifunctional μOR Agonist and σ1R Antagonist with Potent Analgesic Responses and Reduced Adverse Effects. J Med Chem. 2023;66(23):16257-16275.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3009018-61-2