Pomalidomide-C11-NH2

Pomalidomide-C11-NH2

• CAS Number: 2648285-39-4
• UNSPSC Description: Pomalidomide-C11-NH2 is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-C11-NH2 can be connected to the ligand for protein by a linker to form PROTAC[1].
• Target Antigen: E3 Ligase Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pomalidomide-c11-nh2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1N(C(C2=C1C=CC=C2NCCCCCCCCCCCN)=O)C(C(N3)=O)CCC3=O
• Molecular Weight: 442.55
• References & Citations: [1]Chotitumnavee J, et al. Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC). Chem Commun (Camb). 2022 Apr 7;58(29):4635-4638.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported