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Pomalidomide-C11-NH2

CAT: 0804-HY-153337Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-153337Size:1 Each
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Description
Pomalidomide-C11-NH2 is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-C11-NH2 can be connected to the ligand for protein by a linker to form PROTAC[1].
CAS Number
2648285-39-4
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pomalidomide-c11-nh2.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C(C2=C1C=CC=C2NCCCCCCCCCCCN)=O)C(C(N3)=O)CCC3=O
Molecular Formula
C24H34N4O4
Molecular Weight
442.55
References & Citations
[1]Chotitumnavee J, et al. Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC) . Chem Commun (Camb) . 2022 Apr 7;58 (29) :4635-4638.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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