3’-Beta-C-ethynyl-5-trifluoromethyluridine
CAT:
804-HY-152429
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
3’-Beta-C-ethynyl-5-trifluoromethyluridine
- UNSPSC Description: 3’-Beta-C-ethynyl-5-trifluoromethyluridine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis[1]. 3’-Beta-C-ethynyl-5-trifluoromethyluridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Target Antigen: Nucleoside Antimetabolite/Analog
- Type: Oligonucleotides
- Related Pathways: Cell Cycle/DNA Damage
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/3-beta-c-ethynyl-5-trifluoromethyluridine.html
- Solubility: 10 mM in DMSO
- Smiles: O[C@@H]1[C@](O)(C#C)[C@@H](CO)O[C@H]1N(C(N2)=O)C=C(C(F)(F)F)C2=O
- Molecular Weight: 336.22
- References & Citations: [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.|[2]Cavanagh BL, et al. Thymidine analogues for tracking DNA synthesis. Molecules. 2011 Sep 15;16(9):7980-93.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported