2’-beta-C-Ethynyl-5-methyluridine

2’-beta-C-Ethynyl-5-methyluridine

• UNSPSC Description: 2’-beta-C-Ethynyl-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 2’-beta-C-Ethynyl-5-methyluridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Oligonucleotides
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/2-beta-c-ethynyl-5-methyluridine.html
• Solubility: 10 mM in DMSO
• Smiles: O[C@]([C@@H]1O)([C@H](N(C(N2)=O)C=C(C)C2=O)O[C@@H]1CO)C#C
• Molecular Weight: 282.25
• References & Citations: [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported