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SEH inhibitor-10

CAT: 0804-HY-151616Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-151616Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SEH inhibitor-10 (Compound 37) is a selective soluble epoxide hydrolase (sEH) inhibitor (IC50=0.5 μM) . sEH inhibitor-10 maintains high cycloeicosatrienoic acid (EETs) levels by inhibiting sEH, thereby reducing inflammation, regulating endothelial tone, improving mitochondrial function, and reducing oxidative stress. sEH inhibitor-10 has good research potential in metabolic, renal and cardiovascular diseases[1].
UNSPSC
12352005
Target
Epoxide Hydrolase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/seh-inhibitor-10.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(N=C(SCC2=CC=CC=C2C(F)(F)F)N3)=C(C=C1)C3=O)NCC(C)(C)C
Molecular Formula
C22H22F3N3O2S
Molecular Weight
449.49
References & Citations
[1]Turanlı S, et al. Quinazoline-4 (3H) -one-7-carboxamide Derivatives as Human Soluble Epoxide Hydrolase Inhibitors with Developable 5-Lipoxygenase Activating Protein Inhibition. ACS Omega. 2022 Oct 5;7 (41) :36354-36365.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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