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NNMT-IN-3

CAT: 0804-HY-151193Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-151193Size:1 Each
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Description
NNMT-IN-3 (compound 14) is a potent and selective nicotinamide N-methyltransferase NNMT inhibitor with IC50 values of 1.1 nM and 0.4 μM in cell-free and cell-based assays, respectively. NNMT-IN-3 can be used to research obesity, type 2 diabetes, alcohol-related liver disease, cancer, sarcopenia and so on[1].
CAS Number
3031493-74-7
UNSPSC
12352005
Target
Amine N-methyltransferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/nnmt-in-3.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C2C(C=C(N2CC3=CC=C(C=C3)Cl)[C@H]4C[C@@H](CN4C(C5=CC6=C(NC(C)=C6)N=C5)=O)N7N=C(C=C7CN)C)=C1
Molecular Formula
C34H34ClN7O
Molecular Weight
592.13
References & Citations
[1]Yoshida S, et al. Peptide-to-Small Molecule: A Pharmacophore-Guided Small Molecule Lead Generation Strategy from High-Affinity Macrocyclic Peptides. J Med Chem. 2022 Aug 11;65 (15) :10655-10673.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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