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NNMT-IN-6 (hydrochloride)

CAT: 0804-HY-138993A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-138993A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NNMT-IN-6 hydrochloride (compound 78) is a potent nicotinamide N-methyltransferase (NNMT) inhibitor with an IC50 of 1.41 μM and a Kd of 5.6 μM. NNMT-IN-6 hydrochloride shows an inhibitory effect on the cell proliferation of the HSC-2 human oral cancer cell line[1].
CAS Number
3031756-18-7
UNSPSC
12352005
Target
Amine N-methyltransferase
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.21
Smiles
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CN(CC(C=C4)=CC5=C4C=CC=C5)CC[C@@H](C(O)=O)N)O3.Cl
Molecular Formula
C25H30ClN7O5
Molecular Weight
544.00
References & Citations
[1]Gao Y, et al. Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) with Enhanced Activity. J Med Chem. 2019 Jul 25;62 (14) :6597-6614.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NNMT

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