NNMT-IN-5

• UNSPSC Description:

  NNMT-IN-5 (Compound 3-12) is a potent nicotinamide N-methyltransferase (NNMT) inhibitor (IC50 = 47.9 ± 0.6 nM). NNMT-IN-5 also has an excellent selectivity profile over a panel of human methyltransferases. NNMT-IN-5 can be used for the research of cancer, diabetes, metabolic disorders, and neurodegenerative diseases[1].

• Target Antigen:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer; Metabolic Disease; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/nnmt-in-5.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N[C@H](C(O)=O)CCN(CC#CC1=CC=CC(C(N)=O)=C1)C[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C=C(CC)C4=C3N=CN=C4N)O2

• Molecular Weight:

  551.59

• References & Citations:

  [1]Li P, et al. Enhancing nicotinamide N-methyltransferase bisubstrate inhibitor activity through 7-deazaadenosine and linker modifications. Bioorg Chem. 2024 Feb;143:106963.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported