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CYP11B1-IN-2

CAT: 0804-HY-151140Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-151140Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CYP11B1-IN-2 (compound 7aa) is an orally active, potent and selective CYP11B1 inhibitor, with IC50 values of 9 nM and 25 nM for human CYP11B1 and rat CYP11B1, respectively. CYP11B1-IN-2 can be used for the research of diseases caused by excessive cortisol[1].
UNSPSC
12352005
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/cyp11b1-in-2.html
Solubility
10 mM in DMSO
Smiles
[H][C@@]12C(C3=CC=CN=C3)=NO[C@@]1([C@@H]4C[C@H]2CC4)C(NC5=CC6=C(C=C5)NN=C6)=O
Molecular Formula
C21H19N5O2
Molecular Weight
373.41
References & Citations
[1]Yin L, et al. Design, Synthesis, and Biological Evaluations of Pyridyl 4,5,6,7-Tetrahydro-4,7-Methanobenzo[d]isoxazoles as Potent and Selective Inhibitors of 11β-Hydroxylase. J Med Chem. 2022 Aug 17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP1; CYP11; CYP2; CYP3

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