Antiproliferative agent-11

Antiproliferative agent-11

• CAS Number: 9007-83-4
• UNSPSC Description: Antiproliferative agent-11 (compound 7) is an antiproliferative and selective Ruthenium(II)-Tris-pyrazolylmethane complex. Antiproliferative agent-11 shows antiproliferative activity towards MCF-7, HeLa, 518A2, HCT116 and RD with IC50s of 6, 10, 6.8, 6.7 and 6 μM, respectively. Antiproliferative agent-11 can be used for the research of cancer[1].
• Target Antigen: Apoptosis
• Type: Reference compound
• Related Pathways: Apoptosis
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/antiproliferative-agent-11.html
• Solubility: 10 mM in DMSO
• Smiles: [H]c12n3cccn3[Ru+](n4n2ccc4)(Cl)([P](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)([P](OC)(OC)OC)n8n1ccc8.[Cl-]
• Molecular Weight: 772.56
• References & Citations: [1]Cervinka J, et al. Ruthenium(II)-Tris-pyrazolylmethane Complexes Inhibit Cancer Cell Growth by Disrupting Mitochondrial Calcium Homeostasis. J Med Chem. 2022 Aug 1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported