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(Rac) -Lartesertib

CAT: 0804-HY-150617ASize: 1 EachDry Ice: NoHazardous: No
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Description
(Rac) -Lartesertib ((Rac) -M4076) is an isoform of Lartesertib. Lartesertib (M4076) is an inhibitor of the serine/threonine protein kinase ATM with high potency. Lartesertib can inhibit the growth of multiple hematopoietic cell lines. Additionally, when combined with the ATR inhibitor Tuvusertib (HY-111451), Lartesertib can promote the death of tumor cells, activate the immune signaling pathway, and exhibit anti-tumor activity[1][2].
CAS Number
2020089-41-0
Product Name Alternative
(Rac) -M4076; (Rac) -ATM Inhibitor-5
UNSPSC
12352005
Target
ATM/ATR; PD-1/PD-L1; STING
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/rac-lartesertib.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C2=C(N1C)C=NC3=C2C=C(C4=CN(C)N=C4C)C(OC)=C3)C5=C(OC)C=NC=C5F
Molecular Formula
C23H21FN6O3
Molecular Weight
448.45
References & Citations
[1]Mukker J K, et al. In vitro evaluation of myelosuppressive effects of ATRi tuvusertib and ATMi lartesertib (M4076), alone and in combination. Cancer Research, 2024, 84 (6_Supplement) : 7186-7186.|[2]Laaber K, et al. Combined inhibition of ATR and ATM with tuvusertib and lartesertib (M4076) impacts the tumor microenvironment. Cancer Research, 2024, 84 (6_Supplement) : 5617-5617.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

M-4076

Lartesertib is under investigation in clinical trial NCT06433219 (Tuvusertib Combined With Niraparib or Lartesertib in Participants With Epithelial Ovarian Cancer (Ddriver EOC 302)).

CAS Number2020089-41-0
PubChem CID122599280
IUPAC Name8-(1,3-dimethylpyrazol-4-yl)-1-(3-fluoro-5-methoxy-4-pyridinyl)-7-methoxy-3-methylimidazo[4,5-c]quinolin-2-one
Molecular FormulaC23H21FN6O3
Molecular Weight448.4
XLogP2.1
Topological Polar Surface Area85.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Heavy Atom Count33
Formal Charge0
Complexity732
SMILES
CC1=NN(C=C1C2=C(C=C3C(=C2)C4=C(C=N3)N(C(=O)N4C5=C(C=NC=C5OC)F)C)OC)C
InChI
InChI=1S/C23H21FN6O3/c1-12-15(11-28(2)27-12)13-6-14-17(7-19(13)32-4)26-9-18-21(14)30(23(31)29(18)3)22-16(24)8-25-10-20(22)33-5/h6-11H,1-5H3
InChIKey
WNEFOSMCGCLLJU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of M-4076
CAS: 2020089-41-0
CID: 122599280
Formula: C23H21FN6O3
MW: 448.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight448.4
XLogP32.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass448.16591672
Monoisotopic Mass448.16591672
Topological Polar Surface Area85.6 Ų
Heavy Atom Count33
Formal Charge0
Complexity732
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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