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Lartesertib

CAT: 0804-HY-150617-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-150617-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lartesertib (M4076) is an inhibitor of the serine/threonine protein kinase ATM with high potency. Lartesertib can inhibit the growth of multiple hematopoietic cell lines. Additionally, when combined with the ATR inhibitor Tuvusertib , Lartesertib can promote the death of tumor cells, activate the immune signaling pathway, and exhibit anti-tumor activity[1][2].
CAS Number
2495096-26-7
Product Name Alternative
M4076; ATM Inhibitor-5
UNSPSC
12352005
Target
ATM/ATR; PD-1/PD-L1; STING
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/atm-inhibitor-5.html
Purity
99.94
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(N1C2=C(F)C=NC=C2OC)N(C)C3=C1C4=CC(C5=CN(C)N=C5C)=C(OC)C=C4N=C3
Molecular Formula
C23H21FN6O3
Molecular Weight
448.45
References & Citations
[1]Mukker J K, et al. In vitro evaluation of myelosuppressive effects of ATRi tuvusertib and ATMi lartesertib (M4076), alone and in combination. Cancer Research, 2024, 84 (6_Supplement) : 7186-7186.|[2]Laaber K, et al. Combined inhibition of ATR and ATM with tuvusertib and lartesertib (M4076) impacts the tumor microenvironment. Cancer Research, 2024, 84 (6_Supplement) : 5617-5617.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
ATM

Alternative Products

CatalogName
M35661-01Lartesertib
C01451-10mM/1mLLartesertib (M4076)

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