SphK1-IN-2

SphK1-IN-2

• CAS Number: 3031483-60-7
• UNSPSC Description: SphK1-IN-2 is a potent, selective SphK1 inhibitor with IC50 values of 19.81 nM and ＞10 μM for SphK1 and SphK2, respectively. SphK1-IN-2 exhibits anti-proliferative activities and induces cell cycle arrest and apoptosis. SphK1-IN-2 can be used for cancer research[1].
• Target Antigen: Apoptosis; SphK
• Type: Reference compound
• Related Pathways: Apoptosis;Immunology/Inflammation
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/sphk1-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: OC[C@@H]1N(CC2=CC=C(COC3=CC(CS(=O)(C4=CC=CC=C4)=O)=C(Br)C(C)=C3)C=C2)CCC1
• Molecular Weight: 544.50
• References & Citations: [1]Zhang S, et, al. Novel Sphingosine Kinase 1 Inhibitor Suppresses Growth of Solid Tumor and Inhibits the Lung Metastasis of Triple-Negative Breast Cancer. J Med Chem. 2022 Jun 9;65(11):7697-7716.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported