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SphK1-IN-4

CAT: 0804-HY-178992Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178992Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SphK1-IN-4 (Compound 6b) is a sphingosine kinase 1 (SphK1) inhibitor. SphK1-IN-4 exhibit potent and selective cytotoxicity toward A549 and MCF-7 cells with IC50 values of 0.85 and 1.9 μM. SphK1-IN-4 is non-toxic toward Vero cells (LD50 >100 μM) . SphK1-IN-4 can be used for the research of cancer, such as lung cancer[1].
CAS Number
160149-21-3
Target
SphK
Related Pathways
Immunology/Inflammation
Field of Research
Cancer
Smiles
O=C1OC2=C(C=C(Cl)C=C2)C=C1C3=NC4=CC=CC=C4N3
Molecular Formula
C16H9ClN2O2
Molecular Weight
296.71
References & Citations
[1]Arya CG, et al. Coumarin-benzimidazole hybrids: Design, synthesis and identification of potential anticancer agents. Bioorg Med Chem Lett. 2025 Oct 18;131:130444.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SphK1

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