EP39

CAT: 0804-HY-150536Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-150536Size:1 Each
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Description
EP39 is a potent HIV-1 maturation inhibitor. EP39 interacts with the SP1 domain of Gag. EP39 decreases the dynamics of CA-SP1 junction, by binding to the QVT motif of the SP1 domain, and perturbs the natural coil-helix equilibrium on both sides of the SP1 domain by stabilizing the transient alpha helical structure. EP39 acts by arresting maturation of HIV-1 thereby blocking its infectivity[1].
UNSPSC
12352211
Target
HIV; HIV Protease
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ep39.html
Solubility
10 mM in DMSO
Smiles
NCCNC([C@]12C([C@@H](CC2)C(C)=C)C3[C@@](CC1)([C@]4(C([C@@]5(C(C(C)([C@H](CC5)OC(CC(C)(C)C(O)=O)=O)C)CC4)C)CC3)C)C)=O
Molecular Formula
C38H62N2O5
Molecular Weight
626.91
References & Citations
[1]Chen X, et, al. The HIV-1 maturation inhibitor, EP39, interferes with the dynamic helix-coil equilibrium of the CA-SP1 junction of Gag. Eur J Med Chem. 2020 Oct 15;204:112634.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1

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