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Diclofenac-d4

CAT: 0804-HY-15036S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15036S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Diclofenac-d4 is the deuterium labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].
CAS Number
153466-65-0
UNSPSC
12352005
Hazard Statement
H301, H361, H373, H412
Target
Apoptosis; COX; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Immunology/Inflammation; Others
Field of Research
Inflammation/Immunology
Purity
99.79
Solubility
10 mM in DMSO|DMSO : ≥ 30mg/mL|Ethanol : ≥ 30mg/mL
Smiles
OC(CC(C([2H])=C([2H])C([2H])=C1[2H])=C1NC2=C(C=CC=C2Cl)Cl)=O
Molecular Formula
C14H7D4Cl2NO2
Molecular Weight
300.17
Precautions
H301, H361, H373, H412
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121 (1) :105-17.|[3]Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80.|[4]Chiho Kudo, et al. Diclofenac Inhibits Proliferation and Differentiation of Neural Stem Cells. Biochem Pharmacol. 2003 Jul 15;66 (2) :289-95.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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Alternative Products

CatalogName
TRC-D436452-1MGDiclofenac-d4
CS-T-557944-Hydroxy Diclofenac-d4
TRC-H825227-5MG4’-Hydroxy Diclofenac-D4
AR-D01695-014'-Hydroxy Diclofenac-d4
CS-O-49510N-Nitroso Diclofenac-d4
TRC-H825726-10MG3’-Hydroxy Diclofenac-d4
AR-D01722-01Diclofenac-d4 Acyl Glucuronide
TRC-D436451-5MGDiclofenac-d4 Sodium Salt (Phenyl-d4-acetic)
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