Diclofenac amide

CAT: 0804-HY-134521-01Size: 25 gDry Ice: NoHazardous: No

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CAT#:0804-HY-134521-01Size:25 g

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Description

Diclofenac amide is a prodrug for Diclofenac sodium. Diclofenac amide is an orally active inhibitor for COX-1/2, that inhibits the production of prostaglandins (PG) and thromboxanes (TX). Diclofenac amide exhibits anti-inflammatory efficacy in Carrageenan (HY-125474) -induced rat paw edema model without causing gastric ulcer (300 μmol/kg).

CAS Number

15362-40-0

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/diclofenac-amide.html

Purity

99.02

Smiles

O=C1N(C2=C(Cl)C=CC=C2Cl)C3=C(C=CC=C3)C1

Molecular Formula

C14H9Cl2NO

Molecular Weight

278.14

Precautions

H302, H315, H319, H335

References & Citations

[1]Santos JL, et al., Pharmacological evaluation and preliminary pharmacokinetics studies of a new diclofenac prodrug without gastric ulceration effect. Int J Mol Sci. 2012 Nov 19;13 (11) :15305-20.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

Diclofenac lactam

CAS Number	15362-40-0
PubChem CID	27211
IUPAC Name	1-(2,6-dichlorophenyl)-3H-indol-2-one
Molecular Formula	C14H9Cl2NO
Molecular Weight	278.1
XLogP	3.8
Topological Polar Surface Area	20.3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	1
Heavy Atom Count	18
Formal Charge	0
Complexity	326

SMILES

C1C2=CC=CC=C2N(C1=O)C3=C(C=CC=C3Cl)Cl

InChI

InChI=1S/C14H9Cl2NO/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(17)18/h1-7H,8H2

InChIKey

JCICIFOYVSPMHG-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 15362-40-0

CID: 27211

Formula: C14H9Cl2NO

MW: 278.1

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	278.1
XLogP3	3.8
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	1
Exact Mass	277.0061193
Monoisotopic Mass	277.0061193
Topological Polar Surface Area	20.3 Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	326
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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