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Diclofenac (potassium)

CAT: 0804-HY-15038-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15038-01Size:500 mg
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Description
Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].
CAS Number
15307-81-0
UNSPSC
12352005
Hazard Statement
H302, H411
Target
Apoptosis; COX
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/diclofenac-potassium.html
Purity
99.99
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O[K])CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl
Molecular Formula
C14H10Cl2KNO2
Molecular Weight
334.24
Precautions
H302, H411
References & Citations
[1]Chiho Kudo, et al. Diclofenac Inhibits Proliferation and Differentiation of Neural Stem Cells. Biochem Pharmacol. 2003 Jul 15;66 (2) :289-95.|[2]Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121 (1) :105-17.|[3]Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
COX-1; COX-2
Citation 01
Biotechnol Bioeng. 2021 Dec;118 (12) :4687-4698.|ACS Infect Dis. 2024 Aug 9;10 (8) :2860-2869.|Arch Microbiol. 2024 Jun 7;206 (7) :289.|Biotechnol Bioeng. 2021 Dec;118 (12) :4687-4698.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|Phys Chem Chem Phys. 2016 Jan 21;18 (3) :1526-36. |Toxicol Mech Methods. 2019 Nov;29 (9) :654-664.|Anal Chem. 2025 Jun 3;97 (21) :11099-11109.|Biomater Res. 2025 Nov 7:29:0280.|Biomater Res. 2025 Oct 22.|bioRxiv. 2024 Apr 7.|Biotechnol Bioeng. 2021 Dec;118 (12) :4687-4698.|Cell Rep. 2025 Feb 7;44 (2) :115263.|Chem Biol Interact. 2021 Apr 1:338:109425.|Chemosphere. 2019 Jun:225:378-387.|Ecotoxicol Environ Saf. 2025 Nov 15:307:119433.|Eur J Drug Metab Pharmacokinet. 2022 Sep;47 (5) :639-652.|Institute of Chemistry, Federal University of Rio Grande do Sul (UFRGS) . 2017 Nov.|Int J Mol Sci. 2022 Oct 11;23 (20) :12066.|J Hazard Mater. 2015 May 30;289:18-27.|J Pharm Biomed Anal. 2021 Jul 15:201:114105.|J Phys Chem Solids. 2017 October;109:117-123.|Pharm Res. 2022 Oct;39 (10) :2515-2527.

Chemical Information

Diclofenac Potassium

Diclofenac potassium is the potassium salt of diclofenac. It contains a diclofenac(1-).

CAS Number15307-81-0
PubChem CID23667642
IUPAC Namepotassium 2-[2-(2,6-dichloroanilino)phenyl]acetate
Molecular FormulaC14H10Cl2KNO2
Molecular Weight334.2
Topological Polar Surface Area52.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count20
Formal Charge0
Complexity310
SMILES
C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[K+]
InChI
InChI=1S/C14H11Cl2NO2.K/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
InChIKey
KXZOIWWTXOCYKR-UHFFFAOYSA-M
Chemical Structure
2D Structure
2D structure of Diclofenac Potassium
CAS: 15307-81-0
CID: 23667642
Formula: C14H10Cl2KNO2
MW: 334.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight334.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass332.9725654
Monoisotopic Mass332.9725654
Topological Polar Surface Area52.2 Ų
Heavy Atom Count20
Formal Charge0
Complexity310
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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