Diclofenac

• UNSPSC Description:

  Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

• Target Antigen:

  Apoptosis; COX

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Diclofenac.html

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C(O)CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl

• Molecular Weight:

  296.153

• References & Citations:

  [1]Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.|[2]Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80.|[3]Chiho Kudo, et al. Diclofenac Inhibits Proliferation and Differentiation of Neural Stem Cells. Biochem Pharmacol. 2003 Jul 15;66(2):289-95.bioRxiv. 2024 Apr 7.|Biotechnol Bioeng. 2021 Sep 3.|Chem-Biol Interact. 2021, 109425.|Chemosphere. 2019 Jun;225:378-387. |Eur J Drug Metab Pharmacokinet. 2022 Jun 22.|Institute of Chemistry, Federal University of Rio Grande do Sul (UFRGS). 2017 Nov.|Int J Mol Sci. 2022, 23(20), 12066.|J Hazard Mater. 2015 May 30;289:18-27.|J Pharmaceut Biomed. 2021, 114105.|J Phys Chem Solids. 2017 October;109:117-123.|ACS Infect Dis. 2024 Jul 29.|Arch Microbiol. 2024 Jun 7;206(7):289.|Biotechnol Bioeng. 2021 Sep 3.|Cell Rep Methods. 2023 Oct 23;3(10):100599.|Phys Chem Chem Phys. 2016 Jan 21;18(3):1526-36. |Toxicol Mech Methods. 2019 Nov;29(9):654-664.|Biotechnol Bioeng. 2021 Sep 3.|Pharm Res. 2022 Aug 24.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  Launched

• CAS Number:

  15307-86-5