Diclofenac

• Description :

  Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H361, H372, H411

• Target :

  Apoptosis; COX

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Diclofenac.html

• Purity :

  99.98

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C(O)CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl

• Molecular Formula :

  C14H11Cl2NO2

• Molecular Weight :

  296.15

• Precautions :

  H301, H361, H372, H411

• References & Citations :

  [1]Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121 (1) :105-17.|[2]Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80.|[3]Chiho Kudo, et al. Diclofenac Inhibits Proliferation and Differentiation of Neural Stem Cells. Biochem Pharmacol. 2003 Jul 15;66 (2) :289-95.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  COX-1; COX-2

• Citation 01 :

  Anal Chem. 2025 Jun 3;97 (21) :11099-11109.|Biomater Res. 2025 Nov 7:29:0280.|Biomater Res. 2025 Oct 22.|bioRxiv. 2024 Apr 7.|Biotechnol Bioeng. 2021 Dec;118 (12) :4687-4698.|Cell Rep. 2025 Feb 7;44 (2) :115263.|Chem Biol Interact. 2021 Apr 1:338:109425.|Chemosphere. 2019 Jun:225:378-387.|Ecotoxicol Environ Saf. 2025 Nov 15:307:119433.|Eur J Drug Metab Pharmacokinet. 2022 Sep;47 (5) :639-652.|Institute of Chemistry, Federal University of Rio Grande do Sul (UFRGS) . 2017 Nov.|Int J Mol Sci. 2022 Oct 11;23 (20) :12066.|J Hazard Mater. 2015 May 30;289:18-27.|J Pharm Biomed Anal. 2021 Jul 15:201:114105.|J Phys Chem Solids. 2017 October;109:117-123.|ACS Infect Dis. 2024 Aug 9;10 (8) :2860-2869.|Arch Microbiol. 2024 Jun 7;206 (7) :289.|Biotechnol Bioeng. 2021 Dec;118 (12) :4687-4698.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|Phys Chem Chem Phys. 2016 Jan 21;18 (3) :1526-36. |Toxicol Mech Methods. 2019 Nov;29 (9) :654-664.|Biotechnol Bioeng. 2021 Dec;118 (12) :4687-4698.|Pharm Res. 2022 Oct;39 (10) :2515-2527.

• CAS Number :

  [15307-86-5]