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C-Met-IN-18

CAT: 0804-HY-149880Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149880Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
C-Met-IN-18 is ATP competitive type-III c-MET inhibitor of WT and D1228V mutant c-MET. c-Met-IN-18 has inhibitory for WT/D1228V with an IC50 value of 0.013/0.20e.c-Met-IN-18 can be used for the research of c-MET driven cancers[1]. c-Met-IN-18 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
3034863-56-1
UNSPSC
12352005
Target
C-Met/HGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/c-met-in-18.html
Solubility
10 mM in DMSO
Smiles
O=C1NC(C(C2=CC(F)=CC3=C2NN=C3C#C)=CN1[C@H](C4=CC=CC=C4)C)=O
Molecular Formula
C21H15FN4O2
Molecular Weight
374.37
References & Citations
[1]Michaelides IN, et al. Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor. J Med Chem. 2023 Jul 13;66 (13) :8782-8807.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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