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TRPV4 antagonist 4

CAT: 0804-HY-149823Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149823Size:1 Each
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Description
TRPV4 antagonist 4 is a potent TRPV4 antagonist with an IC50 value of 22.65 nM. TRPV4 antagonist 4 inhibits TRPV4 current. TRPV4 antagonist 4 shows protective effects on acute lung injury[1].
CAS Number
2918803-89-9
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/trpv4-antagonist-4.html
Solubility
10 mM in DMSO
Smiles
N#CC1(CCC1)C2=CC=C(N3CCC(CC3)N4C(NC(C)C)=NC5=C(NC(C)=O)C(Cl)=C(Cl)C=C54)C=C2
Molecular Formula
C28H32Cl2N6O
Molecular Weight
539.50
References & Citations
[1]Ai C, et al. Discovery and pharmacological characterization of a novel benzimidazole TRPV4 antagonist with cyanocyclobutyl moiety. Eur J Med Chem. 2023 Mar 5;249:115137.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPV4

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