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ICMT-IN-54

CAT: 0804-HY-149730Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149730Size:1 Each
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Description
ICMT-IN-54 (compound 7c) is an adamantyl analogue and an ICMT inhibitor (IC50=12.4 μM), which can inhibit ICMT Methylation. ICMT-in-54 inhibits BFC (N-biotinyl- (6-aminohexanoic) -S-farnesyl-L-cysteine) methylation in saccharomyces cerevisiae expressing ICMT, which is an indirect effect of inhibiting ICMT methylation[1].
CAS Number
908856-14-4
UNSPSC
12352211
Target
ICMT
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/icmt-in-54.html
Solubility
10 mM in DMSO
Smiles
C/C(C)=C/CC/C(C)=C/CC/C(C)=C/CSC[C@@H](C(O)=O)NC(C12CC3CC(CC(C3)C2)C1)=O
Molecular Formula
C29H45NO3S
Molecular Weight
487.74
References & Citations
[1]Donelson JL, et al. Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase. Bioorg Med Chem Lett. 2006 Aug 15;16 (16) :4420-3.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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