R1-11

• Description :

  R1-11 is an indole ICMT inhibitor with an IC50 of 0.6 μM and has anticancer activity. R1-11 inhibits MDA-MB231 and PC3 cells with IC50s of 2.2 μM and 2.0 μM, respectively[1].

• UNSPSC :

  12352005

• Target :

  ICMT

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/r1-11.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CCCCCCCCN1C(CN(CC)CC)=CC2=CC(C3=CN=C(N)N=C3)=CC=C12

• Molecular Formula :

  C25H37N5

• Molecular Weight :

  407.59

• References & Citations :

  [1]Yang WS et al. Isoprenyl carboxyl methyltransferase inhibitors: a brief review including recent patents. Amino Acids. 2017 Sep;49 (9) :1469-1485.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported