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IR-Crizotinib

CAT: 0804-HY-149696Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-149696Size:1 Each
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Description
IR-Crizotinib is a NF-κB-inducing kinase (NIK) inhibitor that crosses the blood-brain barrier and fluorescently localizes intracranial glioblastoma (GBM) in mice (IC50=3.381 μM) . IR-Crizotinib is conjugated from the near-infrared dye IR-786 and the NF-κB-inducing kinase (NIK) inhibitor Crizotinib. IR-Crizotinib can effectively inhibit the growth and invasion of glioma in vitro and in vivo and can be used in cancer research[1].
CAS Number
[2387927-74-2]
UNSPSC
12352005
Target
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ir-crizotinib.html
Solubility
10 mM in DMSO
Smiles
NC(C(O[C@@H](C1=C(Cl)C=CC(F)=C1Cl)C)=C2)=NC=C2C3=CN(N=C3)C4CCN(C5=C(/C=C/C6=[N+](C)C(C=CC=C7)=C7C6(C)C)CCC/C5=C\C=C8C(C)(C)C(C=CC=C9)=C9N/8C)CC4.[I-]
Molecular Formula
C53H57Cl2FIN7O
Molecular Weight
1024.87
References & Citations
[1]Pflug KM, et al. Cyanine Dye Conjugation Enhances Crizotinib Localization to Intracranial Tumors, Attenuating NF-κB-Inducing Kinase Activity and Glioma Progression. Mol Pharm. 2023 Nov 8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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