Crizotinib (acetate)

CAT: 0804-HY-50878BSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-50878BSize:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Crizotinib (PF-02341066) acetate is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib acetate inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib acetate is also a ROS1 inhibitor. Crizotinib acetate has effective tumor growth inhibition[1][2][3].
CAS Number
[877399-53-6]
Product Name Alternative
PF-02341066 (acetate)
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; c-Met/HGFR; ROS Kinase
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/crizotinib-acetate.html
Solubility
10 mM in DMSO
Smiles
NC1=NC=C(C=C1O[C@H](C)C2=C(C=CC(F)=C2Cl)Cl)C3=CN(N=C3)C4CCNCC4.CC(O)=O
Molecular Formula
C23H26Cl2FN5O3
Molecular Weight
510.39
References & Citations
[1]Zou HY, et al. An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res. 2007, 67 (9), 4408-4417.|[2]Cui JJ, et al. Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK) . J Med Chem. 2011 Sep 22;54 (18) :6342-63.|[3]Christensen JG, et al. Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma. Mol Cancer Ther. 2007, 6 (12 Pt 1), 3314-3322.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

Related Products

CatalogName
HY-50878-01Crizotinib
HY-149696IR-Crizotinib
HY-50878S1Crizotinib-d8
HY-100549-01(S) -Crizotinib
HY-50878S2Crizotinib-d9
HY-50878A-01Crizotinib (hydrochloride)
HY-50878R-01Crizotinib (Standard)
HY-50878SCrizotinib-d5
HY-75468-01Crizotinib impurity 1
HY-50878ASCrizotinib-d9 (hydrochloride)

Alternative Products

CatalogName
T1661L-01Crizotinib acetate
T1661-01Crizotinib
RM-C182606-01(S) -Crizotinib
T8399-01Crizotinib hydrochloride
MBS578906(S)-crizotinib
A3020-100(R)-Crizotinib
007107Crizotinib discontinued
T82049-01IR-Crizotinib

Popular Products