IR-Crizotinib

• Target:

  NF-?B

• Related Pathways:

  NF-?B

• Bioactivity:

  IR-Crizotinib is a conjugate of the near-infrared dye IR-786 and Crizotinib, an NF-?B-inducing kinase (NIK) inhibitor, with an IC50 of 3.381 ?M for intracranial glioblastoma (GBM) localization in mice. It has the ability to cross the blood-brain barrier and fluorescently mark GBM, and demonstrates efficacy in inhibiting glioma proliferation and invasion both in vitro and in vivo, making it significant in cancer research [1].

• Smiles:

  C(\C=C\1/C(C)(C)C=2C(N1C)=CC=CC2)=C\3C(=C(/C=C/C=4C(C)(C)C=5C([N+]4C)=CC=CC5)CCC3)N6CCC(CC6)N7C=C(C=N7)C=8C=C(O[C@H](C)C9=C(Cl)C(F)=CC=C9Cl)C(N)=NC8.[I-]

• Molecular Formula:

  C53H57Cl2FIN7O

• Molecular Weight:

  1024.88

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2387927-74-2