IR-Crizotinib

• Target:

  NF-?B

• Related Pathways:

  NF-?B

• Bioactivity:

  IR-Crizotinib is a conjugate of the near-infrared dye IR-786 and Crizotinib, an NF-?B-inducing kinase (NIK) inhibitor, with an IC50 of 3.381 ?M for intracranial glioblastoma (GBM) localization in mice. It has the ability to cross the blood-brain barrier and fluorescently mark GBM, and demonstrates efficacy in inhibiting glioma proliferation and invasion both in vitro and in vivo, making it significant in cancer research [1].

• Smiles:

  C (\C=C\1/C (C) (C) C=2C (N1C) =CC=CC2) =C\3C (=C (/C=C/C=4C (C) (C) C=5C ([N+]4C) =CC=CC5) CCC3) N6CCC (CC6) N7C=C (C=N7) C=8C=C (O[C@H] (C) C9=C (Cl) C (F) =CC=C9Cl) C (N) =NC8.[I-]

• Molecular Formula:

  C53H57Cl2FIN7O

• Molecular Weight:

  1024.88

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2387927-74-2