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(S) -Crizotinib

CAT: 0804-HY-100549-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100549-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(S) -Crizotinib is a potent and selective MTH1 (mutT homologue) inhibitor with an IC50 of 330 nM. (S) -Crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition, induces an increase in DNA single strand breaks, activates DNA repair in human colon carcinoma cells, and effectively suppresses tumour growth in animal models[1].
CAS Number
1374356-45-2
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Apoptosis; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/_S_-Crizotinib.html
Purity
99.81
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
NC1=NC=C(C2=CN(C3CCNCC3)N=C2)C=C1O[C@H](C4=C(Cl)C=CC(F)=C4Cl)C
Molecular Formula
C21H22Cl2FN5O
Molecular Weight
450.34
Precautions
H315, H319, H320
References & Citations
[1]Huber KV, et al. Stereospecific targeting of MTH1 by (S) -crizotinib as an anticancer strategy. Nature. 2014 Apr 10;508 (7495) :222-7.|[2]Dai X, et al. (S) -crizotinib induces apoptosis in human non-small cell lung cancer cells by activating ROS independent of MTH1. J Exp Clin Cancer Res. 2017 Sep 7;36 (1) :120.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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