HIF-1α-IN-5
CAT:
804-HY-151466-01
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
HIF-1α-IN-5
- CAS Number: 2826221-10-5
- UNSPSC Description: HIF-1α-IN-5 is a HIF-1α inhibitor with an IC50 value of 24 nM (in HEK293T cell). HIF-1α-IN-5 also inhibits MAO-A activity. HIF-1α-IN-5 downregulates VEGF and PDK1 mRNA expressions under hypoxia. HIF-1α-IN-5 can be used in the research of cancer[1].
- Target Antigen: HIF/HIF Prolyl-Hydroxylase; Monoamine Oxidase
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease;Neuronal Signaling
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/hif-1α-in-5.html
- Solubility: DMSO : 125 mg/mL (ultrasonic)
- Smiles: O=C(C1=NOC2=CC=CC=C12)NC3=CC=C(N(C)C)C=C3
- Molecular Weight: 281.31
- References & Citations: [1]Zian Xue, et al. Benzo[d]isoxazole Derivatives as Hypoxia-Inducible Factor (HIF)-1α Inhibitors. ACS Med. Chem. Lett. 2022.
- Shipping Conditions: Blue Ice
- Clinical Information: No Development Reported