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Anticancer agent 157

CAT: 0804-HY-149523Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-149523Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Anticancer agent 157 (compound 15) is a NO inhibitor (IC50=0.62 μg/mL) with anti-inflammatory and anticancer activities. Anticancer agent 157 can bind to iNOS (inducible NO synthase) and caspase 8, causing nuclear fragmentation and chromatin condensation, inducing apoptosis. Anticancer agent 157 inhibits HT29 colon cancer cells (IC50=2.45 μg/mL), Hep-G2 liver cancer cells (IC50=3.25 μg/mL), and B16-F10 murine melanoma cells (IC50=3.84 μg/mL) [1].
CAS Number
[9007-83-4]
UNSPSC
12352005
Target
Apoptosis; Caspase; NO Synthase
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-157.html
Solubility
10 mM in DMSO
Smiles
OC1=C(CO)C(C)=C2CCCC(C)(C)C2=C1
Molecular Formula
C14H20O2
Molecular Weight
220.31
References & Citations
[1]Zentar H, et al. Synthesis of Tricyclic Pterolobirin H Analogue: Evaluation of Anticancer and Anti-Inflammatory Activities and Molecular Docking Investigations. Molecules. 2023 Aug 23;28 (17) :6208.. .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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