VEGFR-2-IN-33

VEGFR-2-IN-33

• UNSPSC Description: VEGFR-2-IN-33 (Compound 4d) is a VEGFR inhibitor (IC50: 61.04 nM). VEGFR-2-IN-33 inhibits HepG2 cell proliferation with an IC50 of 4.31 nM. VEGFR-2-IN-33 can be used for research of hepatocellular carcinoma (HCC)[1].
• Target Antigen: VEGFR
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/vegfr-2-in-33.html
• Solubility: 10 mM in DMSO
• Smiles: O=S(C(C=C1)=CC=C1N=C2SC3=NC4=CC=CC=C4N=C3N2)(NC5=CC=CC=N5)=O
• Molecular Weight: 434.49
• References & Citations: [1]El-Hazek RMM, et al. Novel VEGFR2 inhibitors with thiazoloquinoxaline scaffold targeting hepatocellular carcinoma with lower cardiotoxic impact. Sci Rep. 2023 Aug 25;13(1):13907.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported