VEGFR-2-IN-33

• UNSPSC Description:

  VEGFR-2-IN-33 (Compound 4d) is a VEGFR inhibitor (IC50: 61.04 nM). VEGFR-2-IN-33 inhibits HepG2 cell proliferation with an IC50 of 4.31 nM. VEGFR-2-IN-33 can be used for research of hepatocellular carcinoma (HCC)[1].

• Target Antigen:

  VEGFR

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/vegfr-2-in-33.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=S(C(C=C1)=CC=C1N=C2SC3=NC4=CC=CC=C4N=C3N2)(NC5=CC=CC=N5)=O

• Molecular Weight:

  434.49

• References & Citations:

  [1]El-Hazek RMM, et al. Novel VEGFR2 inhibitors with thiazoloquinoxaline scaffold targeting hepatocellular carcinoma with lower cardiotoxic impact. Sci Rep. 2023 Aug 25;13(1):13907.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported