VEGFR-2-IN-9

VEGFR-2-IN-9

• CAS Number: 408502-06-7
• UNSPSC Description: VEGFR-2-IN-9 (KDR-in-4) is a potent kinase insert domain-containing receptor (KDR/VEGFR2) inhibitor with an IC50 of 7 nM.
• Target Antigen: VEGFR
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/3-[5-[2-[_2-Methoxyethyl_methylamino]ethoxy]-1H-indol-2-yl]-2_1H_-quinolinone.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1NC2=C(C=CC=C2)C=C1C(N3)=CC4=C3C=CC(OCCN(CCOC)C)=C4
• Molecular Weight: 391.46
• References & Citations: [1]Fang YQ, et al. Efficient syntheses of KDR kinase inhibitors using a Pd-catalyzed tandem C-N/Suzuki coupling as the key step. J Org Chem. 2007 Feb 16;72(4):1341-6.|[2]Kinose F, et al. Inhibition of retinal and choroidal neovascularization by a novel KDR kinase inhibitor. Molecular Vision 2005; 11:366-373
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported