VEGFR-2-IN-26

VEGFR-2-IN-26

• CAS Number: 2439096-06-5
• UNSPSC Description: VEGFR-2-IN-26 (compound 5h) is a highly potent VEGFR-2 inhibitor with an IC50 value of 15.5 nM. VEGFR-2-IN-26 has good antiproliferative activity against the leukemic, non-small lung, CNS, ovarian, renal, prostate and breast cancer cells[1].
• Target Antigen: VEGFR
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/vegfr-2-in-26.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(NC3=C4C=CC=CC4=NC(C(NC)=O)=N3)C=C2
• Molecular Weight: 480.44
• References & Citations: [1]Hadi SRAE, et al. Scaffold hopping and redesign approaches for quinazoline based urea derivatives as potent VEGFR-2 inhibitors. Bioorg Chem. 2020 Aug;101:103961.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported