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MHJ-627

CAT: 0804-HY-149412Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149412Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MHJ-627 is a potent ERK5 (MAPK7) inhibitor (IC50: 0.91 μM) . MHJ-627 promotes the mRNA expression of tumor suppressors and anti-metastatic genes, and promotes cancer cell death[1].
UNSPSC
12352005
Target
ERK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mhj-627.html
Solubility
10 mM in DMSO
Smiles
O=C(C[N+]1=CN(CCC(C)C)C2=C1C=CC=C2)C3=C(OCCC(C)C)C4=CC=CC=C4C(OCCC(C)C)=C3.[Br-]
Molecular Formula
C34H45BrN2O3
Molecular Weight
609.64
References & Citations
[1]Hwang J, et al. Identification of a Novel ERK5 (MAPK7) Inhibitor, MHJ-627, and Verification of Its Potent Anticancer Efficacy in Cervical Cancer HeLa Cells. Curr Issues Mol Biol. 2023 Jul 24;45 (7) :6154-6169.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK5

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