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Anticancer agent 139

CAT: 0804-HY-149388Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149388Size:1 Each
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Description
Anticancer agent 139 (Compound 6h) has potent anticancer activity. Anticancer agent 139 displayed a π–cationic interaction with the residue Lys352 of Tublin. Anticancer agent 139 has good anticancer activity against SNB-19, OVCAR-8, and NCI-H40 with PGIs of 86.61, 85.26, and 75.99, respectively. Anticancer agent 139 also has moderate anticancer activity against HOP-62, SNB-75, ACHN, NCI/ADR-RES, 786-O, A549/ATCC, HCT-116, and MDA-MB-231 with PGIs of 67.55, 65.46, 59.09, 59.02, 57.88, 56.88, 56.53, 56.4, and 51.88 respectively[1].
CAS Number
2954795-29-8
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-139.html
Solubility
10 mM in DMSO
Smiles
CC1=CC(C)=C(C=C1)NC2=NN=C(O2)C3=CC(F)=C(C(F)=C3)F
Molecular Formula
C16H12F3N3O
Molecular Weight
319.28
References & Citations
[1]Mohit Agarwal, et al. Design, Synthesis, ADME, and Anticancer Studies of Newer N-Aryl-5- (3,4,5-Trifluorophenyl) -1,3,4-Oxadiazol-2-Amines: An Insight into Experimental and Theoretical Investigations. ACS Omega 2023, 8, 30, 26837-26849.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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