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Anticancer agent 136

CAT: 0804-HY-149367Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149367Size:1 Each
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Description
Anticancer agent 136 (compound 22), a C17-triazole analogue of Geldanamycin (GDM; HY-15230), has an IC50 of 3.38 μM for HDF and a Kd of 3.86 μM for Hsp90. Anticancer agent 136 is an apoptosis-inducing agent[1].
CAS Number
3049419-74-8
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-136.html
Solubility
10 mM in DMSO
Smiles
O=C1C(NCC2=CN(C/C=C/C3=CC=CC=C3)N=N2)=C4C(C(NC(/C(C)=C/C=C\[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)C4)=O)=C1)=O
Molecular Formula
C40H50N6O8
Molecular Weight
742.86
References & Citations
[1]Natalia Skrzypczak, et al. Modifications of geldanamycin via CuAAC altering affinity to chaperone protein Hsp90 and cytotoxicity. Eur J Med Chem. 2023 Aug 5;256:115450.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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