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Anticancer agent 133

CAT: 0804-HY-149344Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-149344Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Anticancer agent 133 (compound Rh2) is an anti-cancer agent with cytotoxic and antimetastatic activities. Anticancer agent 133 induces cell cycle arrest, apoptosis, and autophagy. Anticancer agent 133 also inhibits cell metastasis via suppression of EGFR expression mediated by FAK-regulated integrin β1[1].
CAS Number
[2758905-51-8]
UNSPSC
12352005
Target
Apoptosis; Autophagy; EGFR
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-133.html
Solubility
10 mM in DMSO
Smiles
Cl[Rh]12(Cl)([N]#CC)[N]3=C(C(N2C4=CC=CC=C4)=O)C(Cl)=CC=C3N5C(C6=CC=CC=C6)=CC(C)=[N]51
Molecular Formula
C24H19Cl3N5ORh
Molecular Weight
602.71
References & Citations
[1]Gu YQ, et al. Rhodium (III) -Picolinamide Complexes Act as Anticancer and Antimetastasis Agents via Inducing Apoptosis and Autophagy. J Med Chem. 2023 Jul 27;66 (14) :9592-9606.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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