Anticancer agent 133

• Description:

  Anticancer agent 133 (compound Rh2) is an anti-cancer agent with cytotoxic and antimetastatic activities. Anticancer agent 133 induces cell cycle arrest, apoptosis, and autophagy. Anticancer agent 133 also inhibits cell metastasis via suppression of EGFR expression mediated by FAK-regulated integrin β1[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Autophagy; EGFR

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Autophagy; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/anticancer-agent-133.html

• Solubility:

  10 mM in DMSO

• Smiles:

  Cl[Rh]12(Cl)([N]#CC)[N]3=C(C(N2C4=CC=CC=C4)=O)C(Cl)=CC=C3N5C(C6=CC=CC=C6)=CC(C)=[N]51

• Molecular Formula:

  C24H19Cl3N5ORh

• Molecular Weight:

  602.71

• References & Citations:

  [1]Gu YQ, et al. Rhodium (III) -Picolinamide Complexes Act as Anticancer and Antimetastasis Agents via Inducing Apoptosis and Autophagy. J Med Chem. 2023 Jul 27;66 (14) :9592-9606.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2758905-51-8