Anticancer agent 131

Anticancer agent 131

• CAS Number: 9007-83-4
• UNSPSC Description: HCT-116-IN-1, a γ-lactam-fused pyridone derivative, has anticancer activity and displayed high cytotoxicity against HCT116 cells with an IC50 of 5.59 μM[1].
• Target Antigen: Others
• Type: Reference compound
• Related Pathways: Others
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/anticancer-agent-131.html
• Solubility: 10 mM in DMSO
• Smiles: ClC1=CC=C(O)C(C2=C(C3=CC=C([N+]([O-])=O)C=C3)C(N(C4=CC=CC=C4)C5=C2CN(C6=C(C)C=CC=C6C)C5=O)=O)=C1
• Molecular Weight: 578.01
• References & Citations: [1]An YN, et.al. Unexpected Cascade Sequence Forming the C(sp3)-N/C(sp2)-C(sp2) Bond: Direct Access to γ-Lactam-Fused Pyridones with Anticancer Activity. J Org Chem. 2023 Jul 7;88(13):7998-8009.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported