Anticancer agent 131

• Description :

  HCT-116-IN-1, a γ-lactam-fused pyridone derivative, has anticancer activity and displayed high cytotoxicity against HCT116 cells with an IC50 of 5.59 μM[1].

• UNSPSC :

  12352005

• Target :

  Drug Derivative

• Type :

  Reference compound

• Related Pathways :

  Others

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/anticancer-agent-131.html

• Solubility :

  10 mM in DMSO

• Smiles :

  ClC1=CC=C(O)C(C2=C(C3=CC=C([N+]([O-])=O)C=C3)C(N(C4=CC=CC=C4)C5=C2CN(C6=C(C)C=CC=C6C)C5=O)=O)=C1

• Molecular Formula :

  C33H24ClN3O5

• Molecular Weight :

  578.01

• References & Citations :

  [1]An YN, et.al. Unexpected Cascade Sequence Forming the C (sp3) -N/C (sp2) -C (sp2) Bond: Direct Access to γ-Lactam-Fused Pyridones with Anticancer Activity. J Org Chem. 2023 Jul 7;88 (13) :7998-8009.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2864443-47-8]