Complement C1s-IN-1

Complement C1s-IN-1

• CAS Number: 3033831-40-9
• UNSPSC Description: Complement C1s-IN-1 is a potent, selective, orally active and cross the blood-brain barrier C1s inhibitor with an IC50 value of 36 nM[1].
• Target Antigen: Complement System
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/complement-c1s-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: NC1=C(C(F)=CC(N2C[C@H](C3=NOC(C)=C3)N(C4=CC(F)=CC=C4)CC2)=C5)C5=CN=N1
• Molecular Weight: 422.43
• References & Citations: [1]Ikeda Z, et al. Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway. J Med Chem. 2023 Apr 25.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported