Complement C1s-IN-1

• Description :

  Complement C1s-IN-1 is a potent, selective, orally active and cross the blood-brain barrier C1s inhibitor with an IC50 value of 36 nM[1].

• CAS Number :

  [3033831-40-9]

• UNSPSC :

  12352005

• Target :

  Complement System

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/complement-c1s-in-1.html

• Purity :

  97.77

• Solubility :

  10 mM in DMSO

• Smiles :

  NC1=C(C(F)=CC(N2C[C@H](C3=NOC(C)=C3)N(C4=CC(F)=CC=C4)CC2)=C5)C5=CN=N1

• Molecular Formula :

  C22H20F2N6O

• Molecular Weight :

  422.43

• References & Citations :

  [1]Ikeda Z, et al. Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway. J Med Chem. 2023 Apr 25.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported