Complement C5-IN-1

• Description:

  Compound C5-IN-1 (Compound 7) is a selective allosteric inhibitor of complement component protein C5. Compound C5-IN-1 prevents C5 from being cleaved by C5 convertase, inhibits the cleavage of C5 into C5a and C5b, and thus blocks the formation of membrane attack complex (MAC) . Compound C5-IN-1 has an IC50 of 0.77 μM and 5 nM in 50% human whole blood and 2% human serum to block MAC deposition induced by zymosan, respectively. Compound C5-IN-1 can be used to study diseases related to complement overactivation, such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS) [1].

• UNSPSC:

  12352005

• Target:

  Complement System

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/complement-c5-in-1.html

• Concentration:

  10mM

• Purity:

  99.14

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  COC1=C (OCCCC (C) C) C=C (NC (N[C@H] (C2=C (OC) C=CC=C2) C) =O) C (C (O) =O) =C1

• Molecular Formula:

  C24H32N2O6

• Molecular Weight:

  444.52

• References & Citations:

  [1]Jendza K, et al. A small-molecule inhibitor of C5 complement protein. Nat Chem Biol. 2019 Jul;15 (7) :666-668.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2365402-67-9