C1s Enzyme

• Description:

  C1s Enzyme is a subunit of the complement C1 complex, which activates the complement as a serine protease. C1s Enzyme cleaves LRP5 and LRP6, and thus activates the Wnt/β-Catenin signaling pathway. C1s Enzyme promotes the macrophage M2 polarization and inhibits M1 polarization. C1s Enzyme enhances efferocytosis, exhibits anti-inflammatory activity[1].

• Product Name Alternative:

  Masp-2, c1 esterase, c1-esterase

• UNSPSC:

  12352204

• Target:

  Wnt

• Type:

  Enzyme

• Related Pathways:

  Stem Cell/Wnt

• Field of Research:

  Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/c1s-enzyme.html

• Smiles:

  [C1sEnzyme]

• References & Citations:

  [1]Yuan D, et al. Cytoprotective effects of C1s enzyme in macrophages in atherosclerosis mediated through the LRP5 and Wnt/β-catenin pathway. Mol Immunol. 2024 Feb;166:29-38.

• Shipping Conditions:

  Room temperature

• Storage Conditions:

  Store at -80°C for 2 years

• Scientific Category:

  Enzyme

• Clinical Information:

  No Development Reported