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C1s-IN-1

CAT: 0804-HY-W371164Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W371164Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
C1s-IN-1 (compound A1) is a selective and competitive inhibitor of C1s. C1s-IN-1 binds directly to C1s with a Kd of 9.8 μM[1].
CAS Number
1016866-61-7
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Complement System
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/c1s-in-1.html
Solubility
10 mM in DMSO
Smiles
NC(=N)C1C=NC(=CC=1)N2CCN(CC2)C3=CC=CC=C3
Molecular Formula
C16H19N5
Molecular Weight
281.36
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Xu X, et al. Inhibition of the C1s Protease and the Classical Complement Pathway by 6- (4-Phenylpiperazin-1-yl) Pyridine-3-Carboximidamide and Chemical Analogs. J Immunol. 2024 Feb 15;212 (4) :689-701.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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