Anticancer agent 109

Anticancer agent 109

• CAS Number: 9007-83-4
• UNSPSC Description: Anticancer agent 109 (compound 6-15) is an inhibitor of the Gas6-Axl axis with anti-cancer activity. Anticancer agent 109 inhibits the expression of Gas6 and Axl, and the expression p-PI3K and p-AKT in cancer cells, leads to G1 phase arrest and promotes cancer cells apoptosis, and inhibits tumor growth significantly in nude mouse tumor bearing models[1].
• Target Antigen: TAM Receptor
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/anticancer-agent-109.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(/C(C1=C2C)=C\C3=NC4=C(C=CC=C4)C=C3)NC1=NC(C)=C2O
• Molecular Weight: 317.34
• References & Citations: [1]Bae D, et al. Antitumor effect of 3-(quinolin-2-ylmethylene)-4,6-dimethyl-5-hydroxy-7-azaoxindole down-regulating the Gas6-Axl axis. Eur J Med Chem. 2023 May 5;251:115274.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported