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PAA5

CAT: 0804-HY-149036Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149036Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PAA5 is a methide carbon-centered polynuclear Au (I) cluster. PAA5 can release Au (I) causing Pro-oxidant response and accelerated ferroptosis. PAA5 increases the expression of pH2AX in a time-dependent manner. PAA5 has anticancer activity[1].
UNSPSC
12352005
Target
Endogenous Metabolite; Ferroptosis; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/paa5.html
Solubility
10 mM in DMSO
Smiles
[F-][B+3]([F-])([F-])[F-].[F-][B+3]([F-])([F-])[F-].C1(C(C234[Au@@]56[Au@]27[Au]358[Au]46)=[N]([Au]78)C9=C%10C=CC=C9)=C%10C=CC=C1.[2+]
Molecular Formula
C14H8Au5B2F8N
Molecular Weight
1348.66
References & Citations
[1]Xiao K, et, al. Pro-oxidant response and accelerated ferroptosis caused by synergetic Au (I) release in hypercarbon-centered gold (I) cluster prodrugs. Nat Commun. 2022 Aug 9;13 (1) :4669.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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