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PAA-38

CAT: 0804-HY-172773Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172773Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PAA-38 is a highly potent selective inhibitor targeting bacterial prolyl-tRNA synthetase (ProRS) . PAA-38 againsts Pseudomonas aeruginosa ProRS (PaProRS) with a Kd value of 0.399 nM and an IC50 value of 4.97 nM. PAA-38 againsts human cytoplasmic ProRSs (HsProRS) with an IC50 value of 35.5 nM. PAA-38 demonstrates an in vitro antibacterial activity of minimum inhibitory concentration (MIC) = 4-8 μg/mL[1].
UNSPSC
12352101
Target
Bacterial
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
NC1=NC=NC2=C1C=CC(C3=CC(S(=O)(NC([C@H]4NCCC4)=O)=O)=C(F)C=C3)=C2F
Molecular Formula
C19H17F2N5O3S
Molecular Weight
433.43
References & Citations
[1]Luo Z, et al. Development of potent inhibitors targeting bacterial prolyl-tRNA synthetase through fluorine scanning-directed activity tuning. Eur J Med Chem. 2025 Apr 16;291:117647.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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