eIF4A3-IN-17

eIF4A3-IN-17

• CAS Number: 1402931-75-2
• UNSPSC Description: eIF4A3-IN-17 (compound 61) is a silvestrol (HY-13251) analogue. eIF4A3-IN-17 interferes the assembling of eIF4F translation complex with EC50s of 0.9, 15 and 1.8 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-17 can be used for the research of human cancer pathogenesis[1].
• Target Antigen: Eukaryotic Initiation Factor (eIF)
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/eif4a3-in-17.html
• Purity: 99.56
• Solubility: 10 mM in DMSO
• Smiles: COC1=CC=C([C@@]23OC4=CC(C#N)=CC(OC)=C4[C@]2(O)[C@@H]([C@@H]([C@H]3C5=CC=CC=C5)C(OC)=O)O)C=C1
• Molecular Weight: 487.50
• References & Citations: [1]Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported