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EIF4A3-IN-7

CAT: 0804-HY-145361Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145361Size:1 Each
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Description
EIF4A3-IN-7 is a potent inhibitor of eIF4A3. eIF4A3-IN-7 has the potential for researching cancer and other dysproliferative diseases (extracted from patent WO2019161345A1, Compound 8) [1].
CAS Number
2374759-82-5
UNSPSC
12352005
Target
Eukaryotic Initiation Factor (eIF)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/eif4a3-in-7.html
Solubility
10 mM in DMSO
Smiles
O[C@]12[C@](OC3=CC(OC)=CC(OC)=C32)(C4=CC=C(C=C4)O)[C@@](C5=CC=CC=C5)([H])[C@H]([C@H]1O)C(N)=O
Molecular Formula
C26H25NO7
Molecular Weight
463.48
References & Citations
[1]Yoshiyuki Fukase, et al. Agents and methods for treating dysproliferative diseases. Patent WO2019161345A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EIF4

Chemical Information

eIF4A3-IN-7
CAS Number2374759-82-5
PubChem CID155387375
IUPAC Name(1R,2R,3S,3aR,8bS)-1,8b-dihydroxy-3a-(4-hydroxyphenyl)-6,8-dimethoxy-3-phenyl-2,3-dihydro-1H-cyclopenta[b][1]benzofuran-2-carboxamide
Molecular FormulaC26H25NO7
Molecular Weight463.5
XLogP1.9
Topological Polar Surface Area131
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count34
Formal Charge0
Complexity751
SMILES
COC1=CC2=C(C(=C1)OC)[C@@]3([C@@H]([C@@H]([C@H]([C@@]3(O2)C4=CC=C(C=C4)O)C5=CC=CC=C5)C(=O)N)O)O
InChI
InChI=1S/C26H25NO7/c1-32-17-12-18(33-2)22-19(13-17)34-26(15-8-10-16(28)11-9-15)21(14-6-4-3-5-7-14)20(24(27)30)23(29)25(22,26)31/h3-13,20-21,23,28-29,31H,1-2H3,(H2,27,30)/t20-,21-,23-,25+,26+/m1/s1
InChIKey
CBOHUZROGYCRQJ-VRFYTPIESA-N
Chemical Structure
2D Structure
2D structure of eIF4A3-IN-7
CAS: 2374759-82-5
CID: 155387375
Formula: C26H25NO7
MW: 463.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight463.5
XLogP31.9
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass463.16310214
Monoisotopic Mass463.16310214
Topological Polar Surface Area131 Ų
Heavy Atom Count34
Formal Charge0
Complexity751
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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