EIF4A3-IN-2

• Description:

  EIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM[1].

• UNSPSC:

  12352005

• Target:

  Autophagy; Eukaryotic Initiation Factor (eIF)

• Type:

  Reference compound

• Related Pathways:

  Autophagy; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/eIF4A3-IN-2.html

• Concentration:

  10mM

• Purity:

  99.70

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=CC=C(Br)C=C1)N2CCN(C(C3=C4N(C=C(Br)C=C4)N=C3)=O)C[C@@H]2C5=CC=C(Cl)C=C5

• Molecular Formula:

  C25H19Br2ClN4O2

• Molecular Weight:

  602.70

• References & Citations:

  [1]Iwatani-Yoshihara M, et al. Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay. ACS Chem Biol. 2017 Jul 21;12 (7) :1760-1768.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  EIF4

• CAS Number:

  [2095677-20-4]