GlcN-6-P Synthase-IN-1

GlcN-6-P Synthase-IN-1

• CAS Number: 2447602-44-8
• UNSPSC Description: GlcN-6-P Synthase-IN-1 (Compound 4d) is a Glucosamine-6-phosphate (GlcN-6-P) synthase inhibitor with an IC50 of 3.47 μM. GlcN-6-P Synthase-IN-1 exhibits significant antimicrobial activity. GlcN-6-P Synthase-IN-1 has good penetration in the CNS and is able to inhibit the cytochrome P450, CYP3A4 isoform[1].
• Target Antigen: Bacterial; Cytochrome P450; Fungal
• Type: Reference compound
• Related Pathways: Anti-infection;Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/glcn-6-p-synthase-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: C/C(C1=C(C)N=C(N/N=C/C2=CC=C(C3=CC=CC=C3)C=C2)S1)=N\NC(N)=N
• Molecular Weight: 391.49
• References & Citations: [1]Omar AM, et al. The rational design, synthesis, and antimicrobial investigation of 2-Amino-4-Methylthiazole analogues inhibitors of GlcN-6-P synthase. Bioorg Chem. 2020 Jun;99:103781.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported