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Substance P (6-11)

CAT: 0804-HY-P3889Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P3889Size:1 Each
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Description
Substance P (6-11) is the C-terminal hexapeptideamide of Substance P. Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect[1][2].
CAS Number
51165-07-2
UNSPSC
12352209
Target
Neurokinin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/substance-p-6-11.html
Solubility
10 mM in DMSO
Smiles
CSCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC(CNC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](N)CCC(N)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O
Molecular Formula
C36H52N8O7S
Molecular Weight
740.91
References & Citations
[1]Y Torrens, et al. Substance P (6-11) and natural tachykinins interact with septide-sensitive tachykinin receptors coupled to a phospholipase C in the rat urinary bladder. Neuropeptides. 1997 Jun;31 (3) :243-51.|[2]Y Chiba, et al. Effects of substance P and substance P- (6-11) on hormone release from isolated perfused pancreas: their opposite actions on rat and canine islets. Endocrinology. 1985 Nov;117 (5) :1996-2000.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

Substance P (6-11)

C-terminal hexapeptide of substance P

CAS Number51165-07-2
PubChem CID122140
IUPAC Name(2S)-2-amino-N-[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pentanediamide
Molecular FormulaC36H52N8O7S
Molecular Weight740.9
XLogP0.7
Topological Polar Surface Area283
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count9
Rotatable Bond Count23
Heavy Atom Count52
Formal Charge0
Complexity1190
SMILES
CC(C)C[C@@H](C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)CNC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CCC(=O)N)N
InChI
InChI=1S/C36H52N8O7S/c1-22(2)18-27(35(50)42-26(32(39)47)16-17-52-3)41-31(46)21-40-34(49)28(19-23-10-6-4-7-11-23)44-36(51)29(20-24-12-8-5-9-13-24)43-33(48)25(37)14-15-30(38)45/h4-13,22,25-29H,14-21,37H2,1-3H3,(H2,38,45)(H2,39,47)(H,40,49)(H,41,46)(H,42,50)(H,43,48)(H,44,51)/t25-,26-,27-,28-,29-/m0/s1
InChIKey
JRJICHIAKDIPMB-ZIUUJSQJSA-N
Chemical Structure
2D Structure
2D structure of Substance P (6-11)
CAS: 51165-07-2
CID: 122140
Formula: C36H52N8O7S
MW: 740.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight740.9
XLogP30.7
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count9
Rotatable Bond Count23
Exact Mass740.36796720
Monoisotopic Mass740.36796720
Topological Polar Surface Area283 Ų
Heavy Atom Count52
Formal Charge0
Complexity1190
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
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HY-P3895Substance P (3-11)
HY-P3895A-01Substance P (3-11) (acetate)
HY-P11429[Asp5,6, Me-Phe8] Substance P (5-11)
HY-P3932[Sar4] Substance P (4-11)
HY-P3883[DAla4] Substance P (4-11)
HY-P3890A-01Substance P (5-11) (TFA)

Alternative Products

CatalogName
MBS8247074-01Substance P (6-11)
S8000-13VSubstance P (6-11) (Hexa-Substance P)
GTR19068477-01Substance P (6-11) /Hexa-Substance P
5-01980Substance P (6-11)/Hexa-Substance P
VAC-00172-01[Pyr6]-Substance P (6-11)
GTR19036143-01[Glp6] Substance P (6-11)
S8000-15Substance P [Pyr1] (6-11)
GTR18890382Substance P (6-11) peptide
M40441(Pyr6) -Substance P (6-11)
PE-87366-01Substance P (6-11) /Hexa-Substance P Peptide

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